Isochron Scepter + Silence + Seedborn Muse + Teferi, Mage of Zhalfir Combo

Silence in exile (Silence exiled by Isochron Scepter in exile).

All other permanents on the battlefield.

On each opponent upkeep activate Isochron Scepter to cast Silence, preventing your opponent from casting spells.

Seedborn Muse untaps both Isochron Scepter and the mana required to activate it each turn.

Teferi, Mage of Zhalfir prevents your opponent from playing spells at instant speed before you are able to cast Silence or in response to Silence.

Opponents can't cast spells

Lock