Vilis, Broker of Blood + Assault Suit + Nekusar, the Mindrazer Combo

Assault Suit in hand.

Vilis and Nekusar on the battlefield.

Assault Suit attached to Vilis.

At the beginning of an opponent's upkeep, Assault Suit triggers, giving them control of Vilis.

During that player's next draw step, they draw a card.

Nekusar triggers, dealing 1 damage to that opponent.

Vilis triggers, causing the opponent to draw a card.

Repeat from step 3 until the opponent loses the game either due to drawing from an empty library or by having a life total of 0.

When the opponent loses the game, you regain control of Vilis.

Repeat from step 1 for each remaining opponent.

Each opponent loses the game

Infinite card draw for each opponent

Infinite draw triggers for each opponent

Significant damage