Sephiroth, the Savior (Commander) - Infect

Original Name:

Atraxa, Grand UnifierAtraxa, Grand Unifier

Sephiroth, the Savior
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Utility Artifacts
Enchantments
Battles
Planeswalkers
Utility Lands
Mana Artifacts
Lands
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Personify
12%inclusion2 decks17 decks
11%synergy
Celestial Reunion
6.7%inclusion1 decks15 decks
7%synergy
Sodden Verdure
6.3%inclusion1 decks16 decks
5%synergy
Springleaf Parade
6.3%inclusion1 decks16 decks
6%synergy
Winnowing
5.9%inclusion1 decks17 decks
6%synergy
High Synergy Cards
Prologue to Phyresis
76%inclusion411 decks540 decks
52%synergy
Vraska's Fall
72%inclusion388 decks540 decks
50%synergy
Infectious Inquiry
71%inclusion381 decks540 decks
48%synergy
Ixhel, Scion of Atraxa
66%inclusion356 decks540 decks
47%synergy
Venerated Rotpriest
66%inclusion359 decks540 decks
46%synergy
Skrelv, Defector Mite
65%inclusion350 decks540 decks
46%synergy
Necrogen Rotpriest
56%inclusion303 decks540 decks
45%synergy
Vishgraz, the Doomhive
56%inclusion302 decks540 decks
43%synergy
Atraxa, Praetors' Voice
45%inclusion245 decks540 decks
42%synergy
White Sun's Twilight
54%inclusion289 decks540 decks
42%synergy
Top Cards
Bloated Contaminator
59%inclusion321 decks540 decks
39%synergy
Cankerbloom
59%inclusion319 decks540 decks
38%synergy
Thrummingbird
59%inclusion319 decks540 decks
28%synergy
Vraska, Betrayal's Sting
59%inclusion317 decks540 decks
27%synergy
Ezuri, Stalker of Spheres
57%inclusion308 decks540 decks
25%synergy
Unnatural Restoration
57%inclusion306 decks540 decks
37%synergy
Infectious Bite
56%inclusion304 decks540 decks
38%synergy
Tekuthal, Inquiry Dominus
54%inclusion291 decks540 decks
16%synergy
Phyresis Outbreak
52%inclusion283 decks540 decks
34%synergy
Norn's Decree
52%inclusion280 decks540 decks
36%synergy
Game Changers
Smothering Tithe
16%inclusion85 decks540 decks
-18%synergy
Rhystic Study
15%inclusion82 decks540 decks
-26%synergy
Cyclonic Rift
12%inclusion64 decks540 decks
-22%synergy
Teferi's Protection
11%inclusion57 decks540 decks
-8%synergy
Farewell
11%inclusion57 decks540 decks
-7%synergy
Demonic Tutor
10%inclusion54 decks540 decks
-26%synergy
Vampiric Tutor
6.9%inclusion37 decks540 decks
-23%synergy
The One Ring
5.4%inclusion29 decks540 decks
-16%synergy
Worldly Tutor
5.0%inclusion27 decks540 decks
-13%synergy
Creatures
Blightbelly Rat
50%inclusion270 decks540 decks
35%synergy
Elesh Norn, Mother of Machines
50%inclusion268 decks540 decks
37%synergy
Tainted Observer
48%inclusion259 decks540 decks
33%synergy
Contaminant Grafter
45%inclusion244 decks540 decks
29%synergy
Voidwing Hybrid
44%inclusion237 decks540 decks
28%synergy
Myr Convert
39%inclusion209 decks540 decks
31%synergy
Phyrexian Censor
37%inclusion202 decks540 decks
31%synergy
Norn's Choirmaster
35%inclusion187 decks540 decks
22%synergy
Tyrranax Rex
34%inclusion184 decks540 decks
25%synergy
Evolution Sage
34%inclusion183 decks540 decks
-1%synergy
Bilious Skulldweller
34%inclusion182 decks540 decks
24%synergy
Elesh Norn
33%inclusion177 decks540 decks
27%synergy
Ichor Rats
32%inclusion173 decks540 decks
13%synergy
Vorinclex, Monstrous Raider
32%inclusion171 decks540 decks
6%synergy
Metastatic Evangel
30%inclusion120 decks396 decks
14%synergy
Elesh Norn, Grand Cenobite
29%inclusion159 decks540 decks
22%synergy
Jin-Gitaxias
28%inclusion150 decks540 decks
23%synergy
Venomous Brutalizer
27%inclusion148 decks540 decks
23%synergy
Sheoldred
27%inclusion147 decks540 decks
22%synergy
Glissa Sunslayer
27%inclusion145 decks540 decks
23%synergy
Brimaz, Blight of Oreskos
27%inclusion145 decks540 decks
21%synergy
Skithiryx, the Blight Dragon
27%inclusion144 decks540 decks
12%synergy
Pestilent Syphoner
26%inclusion143 decks540 decks
19%synergy
Phyrexian Swarmlord
26%inclusion141 decks540 decks
14%synergy
Slaughter Singer
26%inclusion138 decks540 decks
22%synergy
Glissa, Herald of Predation
24%inclusion129 decks540 decks
18%synergy
Sheoldred, Whispering One
24%inclusion127 decks540 decks
19%synergy
Blighted Agent
22%inclusion119 decks540 decks
5%synergy
Vorinclex
22%inclusion117 decks540 decks
18%synergy
Paladin of Predation
21%inclusion116 decks540 decks
19%synergy
Phyrexian Obliterator
21%inclusion115 decks540 decks
19%synergy
Crawling Chorus
21%inclusion113 decks540 decks
17%synergy
Phyrexian Vindicator
21%inclusion112 decks540 decks
18%synergy
Vorinclex, Voice of Hunger
21%inclusion112 decks540 decks
17%synergy
Zopandrel, Hunger Dominus
19%inclusion105 decks540 decks
17%synergy
Jin-Gitaxias, Progress Tyrant
19%inclusion104 decks540 decks
16%synergy
Venser, Corpse Puppet
17%inclusion94 decks540 decks
13%synergy
Sheoldred, the Apocalypse
17%inclusion92 decks540 decks
12%synergy
Scheming Aspirant
17%inclusion90 decks540 decks
10%synergy
Jin-Gitaxias, Core Augur
16%inclusion85 decks540 decks
13%synergy
Jawbone Duelist
16%inclusion84 decks540 decks
13%synergy
Birds of Paradise
15%inclusion82 decks540 decks
-29%synergy
Plague Myr
15%inclusion79 decks540 decks
7%synergy
Grafted Butcher
14%inclusion78 decks540 decks
12%synergy
Glissa's Retriever
14%inclusion73 decks540 decks
10%synergy
Tyrranax Atrocity
13%inclusion69 decks540 decks
11%synergy
Annex Sentry
13%inclusion68 decks540 decks
11%synergy
Roaming Throne
12%inclusion63 decks540 decks
8%synergy
Plague Nurse
12%inclusion63 decks540 decks
10%synergy
Ria Ivor, Bane of Bladehold
11%inclusion61 decks540 decks
10%synergy
Instants
Swords to Plowshares
48%inclusion259 decks540 decks
-11%synergy
Experimental Augury
48%inclusion257 decks540 decks
28%synergy
Reject Imperfection
33%inclusion177 decks540 decks
25%synergy
Counterspell
29%inclusion159 decks540 decks
-2%synergy
Bring the Ending
27%inclusion148 decks540 decks
23%synergy
Whisper of the Dross
26%inclusion139 decks540 decks
19%synergy
Ephemerate
23%inclusion126 decks540 decks
12%synergy
Path to Exile
21%inclusion112 decks540 decks
-11%synergy
Black Sun's Twilight
16%inclusion85 decks540 decks
14%synergy
Serum Snare
15%inclusion81 decks540 decks
10%synergy
Beast Within
15%inclusion80 decks540 decks
3%synergy
Atomize
13%inclusion67 decks520 decks
0%synergy
Heroic Intervention
12%inclusion65 decks540 decks
-5%synergy
Anoint with Affliction
12%inclusion65 decks540 decks
10%synergy
Sheoldred's Edict
11%inclusion62 decks540 decks
10%synergy
Tainted Strike
11%inclusion61 decks540 decks
3%synergy
Radstorm
11%inclusion57 decks540 decks
1%synergy
Noxious Revival
10%inclusion53 decks540 decks
2%synergy
Mortify
10%inclusion52 decks540 decks
4%synergy
Assassin's Trophy
9.4%inclusion51 decks540 decks
-10%synergy
Negate
9.1%inclusion49 decks540 decks
-1%synergy
Cloudshift
9.1%inclusion49 decks540 decks
3%synergy
Dark Ritual
8.7%inclusion47 decks540 decks
-7%synergy
Mana Drain
8.5%inclusion46 decks540 decks
-10%synergy
Putrefy
8.5%inclusion46 decks540 decks
3%synergy
Momentary Blink
8.3%inclusion45 decks540 decks
4%synergy
Tyvar's Stand
8.1%inclusion44 decks540 decks
7%synergy
Aspirant's Ascent
7.8%inclusion42 decks540 decks
6%synergy
Ghostly Flicker
7.6%inclusion41 decks540 decks
1%synergy
Charge of the Mites
7.4%inclusion40 decks540 decks
6%synergy
Offer Immortality
7.2%inclusion39 decks540 decks
6%synergy
Compleat Devotion
6.5%inclusion35 decks540 decks
6%synergy
Anguished Unmaking
6.1%inclusion33 decks540 decks
-6%synergy
Harmonized Crescendo
5.9%inclusion1 decks17 decks
6%synergy
Eerie Interlude
5.2%inclusion28 decks540 decks
0%synergy
An Offer You Can't Refuse
5.2%inclusion28 decks540 decks
-17%synergy
Sorceries
Cultivate
47%inclusion254 decks540 decks
15%synergy
Drown in Ichor
46%inclusion248 decks540 decks
30%synergy
Expand the Sphere
45%inclusion244 decks540 decks
37%synergy
Thirsting Roots
44%inclusion238 decks540 decks
32%synergy
Farseek
41%inclusion223 decks540 decks
2%synergy
Vat Emergence
26%inclusion140 decks540 decks
20%synergy
Tezzeret's Gambit
23%inclusion125 decks540 decks
-5%synergy
Rampant Growth
22%inclusion118 decks540 decks
5%synergy
Distorted Curiosity
21%inclusion114 decks540 decks
17%synergy
Nature's Lore
21%inclusion113 decks540 decks
-5%synergy
Green Sun's Twilight
21%inclusion111 decks540 decks
19%synergy
Kodama's Reach
19%inclusion102 decks540 decks
1%synergy
Three Visits
18%inclusion96 decks540 decks
-4%synergy
Noxious Assault
16%inclusion84 decks540 decks
13%synergy
Geth's Summons
15%inclusion83 decks540 decks
12%synergy
Vivisurgeon's Insight
14%inclusion77 decks540 decks
11%synergy
Sunfall
11%inclusion62 decks540 decks
7%synergy
Carnivorous Canopy
11%inclusion61 decks540 decks
8%synergy
Feed the Infection
11%inclusion58 decks540 decks
9%synergy
Breach the Multiverse
10%inclusion56 decks540 decks
8%synergy
Blue Sun's Twilight
10%inclusion55 decks540 decks
9%synergy
Phyrexian Rebirth
10%inclusion53 decks540 decks
8%synergy
Triumph of the Hordes
7.4%inclusion40 decks540 decks
3%synergy
Skyshroud Claim
6.7%inclusion36 decks540 decks
1%synergy
Contentious Plan
6.1%inclusion33 decks540 decks
-6%synergy
Against All Odds
6.1%inclusion33 decks540 decks
5%synergy
Supreme Verdict
5.6%inclusion30 decks540 decks
-6%synergy
Merciless Eviction
5.6%inclusion30 decks540 decks
0%synergy
Toxic Deluge
5.6%inclusion30 decks540 decks
-10%synergy
Damn
5.4%inclusion29 decks540 decks
-3%synergy
Culling Ritual
5.0%inclusion27 decks540 decks
-9%synergy
Utility Artifacts
Realmbreaker, the Invasion Tree
26%inclusion138 decks540 decks
22%synergy
Swiftfoot Boots
19%inclusion101 decks540 decks
4%synergy
Lightning Greaves
15%inclusion83 decks540 decks
-3%synergy
Grafted Exoskeleton
14%inclusion73 decks540 decks
8%synergy
Infested Fleshcutter
13%inclusion70 decks540 decks
12%synergy
Norn's Annex
13%inclusion68 decks540 decks
7%synergy
Ichormoon Gauntlet
11%inclusion60 decks540 decks
-1%synergy
Monument to Perfection
11%inclusion58 decks540 decks
10%synergy
Portal to Phyrexia
9.4%inclusion51 decks540 decks
8%synergy
Conduit of Worlds
8.9%inclusion48 decks540 decks
7%synergy
Urza's Incubator
8.7%inclusion47 decks540 decks
7%synergy
Panharmonicon
8.3%inclusion45 decks540 decks
1%synergy
Prosthetic Injector
8.1%inclusion44 decks540 decks
6%synergy
Contagion Engine
7.6%inclusion41 decks540 decks
-9%synergy
Contagion Clasp
7.0%inclusion38 decks540 decks
-2%synergy
Vat of Rebirth
6.7%inclusion36 decks540 decks
5%synergy
Trailblazer's Boots
5.2%inclusion28 decks540 decks
3%synergy
Enchantments
Phyrexian Arena
46%inclusion247 decks540 decks
31%synergy
Skrelv's Hive
43%inclusion230 decks540 decks
32%synergy
Necrogen Communion
38%inclusion207 decks540 decks
32%synergy
Inexorable Tide
24%inclusion130 decks540 decks
-4%synergy
Phyrexian Awakening
18%inclusion96 decks540 decks
14%synergy
Mesmerizing Dose
13%inclusion72 decks540 decks
11%synergy
Teleportation Circle
13%inclusion68 decks540 decks
6%synergy
Ghostly Prison
12%inclusion65 decks540 decks
2%synergy
Ossification
10%inclusion53 decks540 decks
9%synergy
Phyresis
7.8%inclusion42 decks540 decks
3%synergy
Sculpted Perfection
7.6%inclusion41 decks540 decks
5%synergy
Mystic Remora
6.9%inclusion37 decks540 decks
-21%synergy
Innkeeper's Talent
6.4%inclusion22 decks345 decks
-6%synergy
Brokers Ascendancy
6.1%inclusion33 decks540 decks
-14%synergy
Planar Disruption
5.7%inclusion31 decks540 decks
5%synergy
Propaganda
5.4%inclusion29 decks540 decks
-3%synergy
Battles
Invasion of Zendikar
7.0%inclusion38 decks540 decks
5%synergy
Invasion of Ikoria
5.2%inclusion28 decks540 decks
1%synergy
Planeswalkers
The Eternal Wanderer
26%inclusion139 decks540 decks
15%synergy
Ajani, Sleeper Agent
21%inclusion116 decks540 decks
7%synergy
Nissa, Ascended Animist
20%inclusion107 decks540 decks
15%synergy
Tamiyo, Compleated Sage
8.0%inclusion43 decks540 decks
3%synergy
Kaito, Dancing Shadow
5.7%inclusion31 decks540 decks
5%synergy
Jace, the Perfected Mind
5.0%inclusion27 decks540 decks
4%synergy
Utility Lands
Karn's Bastion
50%inclusion268 decks540 decks
14%synergy
Reliquary Tower
39%inclusion211 decks540 decks
13%synergy
The Fair Basilica
22%inclusion121 decks540 decks
20%synergy
The Hunter Maze
21%inclusion112 decks540 decks
19%synergy
The Dross Pits
19%inclusion101 decks540 decks
17%synergy
The Surgical Bay
19%inclusion101 decks540 decks
17%synergy
Rogue's Passage
13%inclusion69 decks540 decks
1%synergy
Bojuka Bog
12%inclusion65 decks540 decks
1%synergy
Yavimaya, Cradle of Growth
10%inclusion53 decks540 decks
-4%synergy
Inkmoth Nexus
8.7%inclusion47 decks540 decks
1%synergy
Boseiju, Who Endures
7.8%inclusion42 decks540 decks
-20%synergy
Temple of the False God
7.2%inclusion39 decks540 decks
1%synergy
Urborg, Tomb of Yawgmoth
6.5%inclusion35 decks540 decks
-5%synergy
Mistrise Village
6.1%inclusion6 decks99 decks
-3%synergy
The Monumental Facade
5.4%inclusion29 decks540 decks
4%synergy
Otawara, Soaring City
5.4%inclusion29 decks540 decks
-17%synergy
Mana Artifacts
Sol Ring
87%inclusion471 decks540 decks
0%synergy
Arcane Signet
79%inclusion424 decks540 decks
-1%synergy
Glistening Sphere
55%inclusion299 decks540 decks
38%synergy
Chromatic Lantern
51%inclusion274 decks540 decks
15%synergy
Phyrexian Atlas
38%inclusion207 decks540 decks
33%synergy
Staff of Compleation
31%inclusion165 decks540 decks
20%synergy
Fellwar Stone
28%inclusion153 decks540 decks
-6%synergy
Commander's Sphere
27%inclusion148 decks540 decks
15%synergy
Thought Vessel
19%inclusion102 decks540 decks
9%synergy
Astral Cornucopia
8.3%inclusion45 decks540 decks
-18%synergy
Everflowing Chalice
8.0%inclusion43 decks540 decks
-14%synergy
Decanter of Endless Water
7.6%inclusion41 decks540 decks
3%synergy
Patchwork Banner
7.6%inclusion26 decks344 decks
6%synergy
Golgari Signet
5.0%inclusion27 decks540 decks
0%synergy
Talisman of Dominance
5.0%inclusion27 decks540 decks
-4%synergy
Lands
Swamp
96%inclusion521 decks540 decks
21%synergy
Forest
96%inclusion521 decks540 decks
19%synergy
Island
96%inclusion517 decks540 decks
18%synergy
Plains
95%inclusion515 decks540 decks
20%synergy
Command Tower
89%inclusion482 decks540 decks
-3%synergy
Exotic Orchard
60%inclusion322 decks540 decks
-6%synergy
Path of Ancestry
52%inclusion283 decks540 decks
28%synergy
The Seedcore
48%inclusion261 decks540 decks
39%synergy
Sandsteppe Citadel
33%inclusion180 decks540 decks
9%synergy
Overgrown Tomb
32%inclusion173 decks540 decks
-14%synergy
Terramorphic Expanse
31%inclusion169 decks540 decks
16%synergy
Breeding Pool
29%inclusion159 decks540 decks
-23%synergy
Spara's Headquarters
29%inclusion154 decks540 decks
-3%synergy
Indatha Triome
28%inclusion150 decks540 decks
-3%synergy
Mirrex
28%inclusion149 decks540 decks
23%synergy
Godless Shrine
28%inclusion149 decks540 decks
-15%synergy
Temple Garden
27%inclusion148 decks540 decks
-16%synergy
Watery Grave
27%inclusion148 decks540 decks
-21%synergy
Evolving Wilds
27%inclusion144 decks540 decks
9%synergy
Hallowed Fountain
27%inclusion144 decks540 decks
-19%synergy
Canopy Vista
26%inclusion138 decks540 decks
10%synergy
Zagoth Triome
26%inclusion138 decks540 decks
-6%synergy
Raffine's Tower
25%inclusion136 decks540 decks
-2%synergy
Seachrome Coast
24%inclusion128 decks540 decks
20%synergy
Opulent Palace
23%inclusion124 decks540 decks
0%synergy
Arcane Sanctum
21%inclusion112 decks540 decks
-1%synergy
The Mycosynth Gardens
21%inclusion111 decks540 decks
18%synergy
Seaside Citadel
20%inclusion108 decks540 decks
-2%synergy
Windswept Heath
20%inclusion106 decks540 decks
-27%synergy
Misty Rainforest
19%inclusion104 decks540 decks
-26%synergy
Razorverge Thicket
19%inclusion103 decks540 decks
15%synergy
Verdant Catacombs
19%inclusion102 decks540 decks
-26%synergy
Polluted Delta
19%inclusion102 decks540 decks
-26%synergy
Flooded Strand
19%inclusion101 decks540 decks
-26%synergy
Marsh Flats
18%inclusion99 decks540 decks
-26%synergy
Rejuvenating Springs
17%inclusion93 decks540 decks
-6%synergy
Darkslick Shores
17%inclusion91 decks540 decks
13%synergy
Myriad Landscape
16%inclusion88 decks540 decks
10%synergy
Bountiful Promenade
15%inclusion83 decks540 decks
-4%synergy
Undergrowth Stadium
15%inclusion82 decks540 decks
-5%synergy
Vault of Champions
15%inclusion80 decks540 decks
-1%synergy
Morphic Pool
15%inclusion79 decks540 decks
-3%synergy
Prairie Stream
14%inclusion77 decks540 decks
2%synergy
Sea of Clouds
14%inclusion74 decks540 decks
-6%synergy
Sunken Hollow
13%inclusion72 decks540 decks
2%synergy
Cavern of Souls
13%inclusion70 decks540 decks
2%synergy
Reflecting Pool
12%inclusion65 decks540 decks
-6%synergy
Yavimaya Coast
11%inclusion58 decks540 decks
-1%synergy
Dismal Backwater
10%inclusion55 decks540 decks
7%synergy
Dreamroot Cascade
10%inclusion55 decks540 decks
2%synergy
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