Skithiryx, the Blight Dragon (Commander) - Core Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #780
42decks
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Plague Stinger
74%inclusion31 decks42 decks
73%synergy
Plague Myr
71%inclusion30 decks42 decks
70%synergy
Infectious Inquiry
69%inclusion29 decks42 decks
66%synergy
Hand of the Praetors
67%inclusion28 decks42 decks
66%synergy
Lashwrithe
69%inclusion29 decks42 decks
65%synergy
Drown in Ichor
67%inclusion28 decks42 decks
62%synergy
Vraska's Fall
64%inclusion27 decks42 decks
61%synergy
Ichor Rats
62%inclusion26 decks42 decks
59%synergy
Phyrexian Crusader
60%inclusion25 decks42 decks
59%synergy
Ichorclaw Myr
57%inclusion24 decks42 decks
57%synergy
Top Cards
Feed the Swarm
62%inclusion26 decks42 decks
11%synergy
Swiftfoot Boots
60%inclusion25 decks42 decks
28%synergy
Whispering Specter
57%inclusion24 decks42 decks
56%synergy
Dark Ritual
57%inclusion24 decks42 decks
-9%synergy
Blightbelly Rat
57%inclusion24 decks42 decks
53%synergy
Crypt Ghast
57%inclusion24 decks42 decks
9%synergy
Core Prowler
55%inclusion23 decks42 decks
54%synergy
Defile
55%inclusion23 decks42 decks
17%synergy
Corpse Cur
55%inclusion23 decks42 decks
54%synergy
Blackblade Reforged
55%inclusion23 decks42 decks
52%synergy
Creatures
Reaper of Sheoldred
52%inclusion22 decks42 decks
52%synergy
Bilious Skulldweller
50%inclusion21 decks42 decks
49%synergy
Flensermite
48%inclusion20 decks42 decks
47%synergy
Flesh-Eater Imp
40%inclusion17 decks42 decks
40%synergy
Septic Rats
40%inclusion17 decks42 decks
38%synergy
Pestilent Syphoner
36%inclusion15 decks42 decks
35%synergy
Myr Convert
36%inclusion15 decks42 decks
35%synergy
Solemn Simulacrum
33%inclusion14 decks42 decks
10%synergy
Phyrexian Obliterator
33%inclusion14 decks42 decks
22%synergy
Necropede
33%inclusion14 decks42 decks
33%synergy
Phyrexian Juggernaut
26%inclusion11 decks42 decks
26%synergy
Leaden Myr
26%inclusion11 decks42 decks
20%synergy
K'rrik, Son of Yawgmoth
24%inclusion10 decks42 decks
5%synergy
Contagious Nim
21%inclusion9 decks42 decks
21%synergy
Gulping Scraptrap
21%inclusion9 decks42 decks
21%synergy
Dread Presence
19%inclusion8 decks42 decks
4%synergy
Yawgmoth, Thran Physician
19%inclusion8 decks42 decks
9%synergy
Gray Merchant of Asphodel
17%inclusion7 decks42 decks
-35%synergy
Swamp Mosquito
17%inclusion7 decks42 decks
17%synergy
Defiler of Flesh
14%inclusion6 decks42 decks
10%synergy
Silent Arbiter
14%inclusion6 decks42 decks
13%synergy
Dark Confidant
14%inclusion6 decks42 decks
7%synergy
Magus of the Coffers
14%inclusion6 decks42 decks
7%synergy
Burnished Hart
14%inclusion6 decks42 decks
6%synergy
Nirkana Revenant
14%inclusion6 decks42 decks
3%synergy
Blightsteel Colossus
14%inclusion6 decks42 decks
14%synergy
Sheoldred's Headcleaver
14%inclusion6 decks42 decks
14%synergy
Massacre Girl, Known Killer
14%inclusion6 decks42 decks
11%synergy
Blackcleave Goblin
12%inclusion5 decks42 decks
12%synergy
Vector Asp
12%inclusion5 decks42 decks
12%synergy
Necroskitter
12%inclusion5 decks42 decks
9%synergy
Sheoldred, Whispering One
12%inclusion5 decks42 decks
0%synergy
Brass Squire
12%inclusion5 decks42 decks
11%synergy
Grafted Butcher
12%inclusion5 decks42 decks
12%synergy
Nimraiser Paladin
10%inclusion4 decks42 decks
9%synergy
Palladium Myr
10%inclusion4 decks42 decks
8%synergy
Toxic Nim
10%inclusion4 decks42 decks
9%synergy
Phyrexian Vatmother
10%inclusion4 decks42 decks
9%synergy
Feral Deathgorger
7.7%inclusion2 decks26 decks
7%synergy
Scavenger Regent
7.7%inclusion2 decks26 decks
7%synergy
Qarsi Revenant
7.7%inclusion2 decks26 decks
3%synergy
Dune Mover
7.1%inclusion3 decks42 decks
7%synergy
Paragon of Open Graves
7.1%inclusion3 decks42 decks
6%synergy
Massacre Girl
7.1%inclusion3 decks42 decks
0%synergy
Scheming Aspirant
7.1%inclusion3 decks42 decks
7%synergy
Massacre Wurm
7.1%inclusion3 decks42 decks
-10%synergy
Phyrexian Digester
7.1%inclusion3 decks42 decks
7%synergy
Suspicious Bookcase
7.1%inclusion3 decks42 decks
7%synergy
Agent Venom
7.1%inclusion1 decks14 decks
5%synergy
Swarm, Being of Bees
7.1%inclusion1 decks14 decks
7%synergy
Instants
Howl from Beyond
50%inclusion21 decks42 decks
49%synergy
Grim Affliction
45%inclusion19 decks42 decks
43%synergy
Tainted Strike
43%inclusion18 decks42 decks
40%synergy
Whisper of the Dross
38%inclusion16 decks42 decks
35%synergy
Go for the Throat
31%inclusion13 decks42 decks
8%synergy
Virulent Wound
29%inclusion12 decks42 decks
28%synergy
Dismember
29%inclusion12 decks42 decks
18%synergy
Withering Torment
28%inclusion10 decks36 decks
-4%synergy
Imp's Mischief
26%inclusion11 decks42 decks
2%synergy
Infernal Grasp
24%inclusion10 decks42 decks
-1%synergy
Sugar Rush
24%inclusion10 decks42 decks
23%synergy
Supernatural Stamina
21%inclusion9 decks42 decks
14%synergy
Doom Blade
21%inclusion9 decks42 decks
14%synergy
Malakir Rebirth
21%inclusion9 decks42 decks
-1%synergy
Snuff Out
19%inclusion8 decks42 decks
6%synergy
Astarion's Thirst
17%inclusion7 decks42 decks
15%synergy
Hero's Downfall
17%inclusion7 decks42 decks
10%synergy
Force of Despair
17%inclusion7 decks42 decks
9%synergy
Anoint with Affliction
17%inclusion7 decks42 decks
16%synergy
Unlikely Aid
17%inclusion7 decks42 decks
16%synergy
Murder
17%inclusion7 decks42 decks
6%synergy
Consuming Corruption
15%inclusion6 decks39 decks
-1%synergy
Undying Malice
14%inclusion6 decks42 decks
5%synergy
Sudden Spoiling
12%inclusion5 decks42 decks
3%synergy
Tragic Slip
12%inclusion5 decks42 decks
-8%synergy
Fell the Profane
10%inclusion4 decks39 decks
-9%synergy
Grotesque Mutation
10%inclusion4 decks42 decks
9%synergy
Sheoldred's Edict
10%inclusion4 decks42 decks
-5%synergy
Unnatural Endurance
10%inclusion4 decks42 decks
9%synergy
Hatred
10%inclusion4 decks42 decks
9%synergy
Grasp of Darkness
10%inclusion4 decks42 decks
7%synergy
Baleful Mastery
10%inclusion4 decks42 decks
0%synergy
Armor of Shadows
10%inclusion4 decks42 decks
7%synergy
Withering Boon
10%inclusion4 decks42 decks
5%synergy
Professor's Warning
10%inclusion4 decks42 decks
8%synergy
Darkness
7.1%inclusion3 decks42 decks
-3%synergy
Cabal Ritual
7.1%inclusion3 decks42 decks
-11%synergy
Lash of Thorns
7.1%inclusion3 decks42 decks
7%synergy
Rush of Vitality
7.1%inclusion3 decks42 decks
6%synergy
Offer Immortality
7.1%inclusion3 decks42 decks
5%synergy
Scorpion's Sting
5.9%inclusion1 decks17 decks
6%synergy
Archenemy's Charm
5.6%inclusion1 decks18 decks
-3%synergy
Sorceries
Phyresis Outbreak
52%inclusion22 decks42 decks
51%synergy
Sign in Blood
48%inclusion20 decks42 decks
12%synergy
Night's Whisper
43%inclusion18 decks42 decks
18%synergy
Caress of Phyrexia
36%inclusion15 decks42 decks
35%synergy
Read the Bones
36%inclusion15 decks42 decks
18%synergy
Crux of Fate
31%inclusion13 decks42 decks
30%synergy
Vat Emergence
26%inclusion11 decks42 decks
25%synergy
Spread the Sickness
24%inclusion10 decks42 decks
23%synergy
Diabolic Tutor
24%inclusion10 decks42 decks
9%synergy
Mutilate
24%inclusion10 decks42 decks
6%synergy
Toxic Deluge
21%inclusion9 decks42 decks
-16%synergy
Black Sun's Zenith
19%inclusion8 decks42 decks
13%synergy
In Garruk's Wake
17%inclusion7 decks42 decks
13%synergy
Feed the Infection
14%inclusion6 decks42 decks
14%synergy
Bubbling Muck
14%inclusion6 decks42 decks
-1%synergy
Geth's Summons
14%inclusion6 decks42 decks
14%synergy
Exsanguinate
14%inclusion6 decks42 decks
-10%synergy
Reanimate
14%inclusion6 decks42 decks
-25%synergy
Ancient Craving
10%inclusion4 decks42 decks
7%synergy
Ambition's Cost
10%inclusion4 decks42 decks
6%synergy
Blasphemous Edict
9.1%inclusion3 decks33 decks
-8%synergy
Insatiable Avarice
7.5%inclusion3 decks40 decks
-5%synergy
Extinction Event
7.1%inclusion3 decks42 decks
7%synergy
Profane Tutor
7.1%inclusion3 decks42 decks
3%synergy
Damnation
7.1%inclusion3 decks42 decks
-14%synergy
Syphon Mind
7.1%inclusion3 decks42 decks
-6%synergy
Nighthaze
7.1%inclusion3 decks42 decks
7%synergy
Languish
7.1%inclusion3 decks42 decks
6%synergy
Prison Break
7.1%inclusion1 decks14 decks
7%synergy
Risky Research
5.9%inclusion1 decks17 decks
5%synergy
Lethal Protection
5.9%inclusion1 decks17 decks
6%synergy
Venom's Hunger
5.9%inclusion1 decks17 decks
6%synergy
Final Vengeance
5.6%inclusion2 decks36 decks
4%synergy
Utility Artifacts
Nightmare Lash
48%inclusion20 decks42 decks
45%synergy
Fireshrieker
48%inclusion20 decks42 decks
46%synergy
Contagion Clasp
45%inclusion19 decks42 decks
43%synergy
Jet Medallion
40%inclusion17 decks42 decks
-20%synergy
Lightning Greaves
36%inclusion15 decks42 decks
2%synergy
Wayfarer's Bauble
33%inclusion14 decks42 decks
17%synergy
Whispersilk Cloak
33%inclusion14 decks42 decks
27%synergy
Contagion Engine
31%inclusion13 decks42 decks
29%synergy
Champion's Helm
29%inclusion12 decks42 decks
27%synergy
Hero's Blade
29%inclusion12 decks42 decks
28%synergy
Trailblazer's Boots
26%inclusion11 decks42 decks
24%synergy
Nettlecyst
19%inclusion8 decks42 decks
18%synergy
Cranial Plating
19%inclusion8 decks42 decks
16%synergy
Strata Scythe
19%inclusion8 decks42 decks
18%synergy
Leyline Axe
18%inclusion6 decks33 decks
17%synergy
Throne of Geth
17%inclusion7 decks42 decks
16%synergy
Inquisitor's Flail
17%inclusion7 decks42 decks
16%synergy
Loxodon Warhammer
17%inclusion7 decks42 decks
15%synergy
Sword of Vengeance
17%inclusion7 decks42 decks
16%synergy
Expedition Map
14%inclusion6 decks42 decks
2%synergy
Commander's Plate
14%inclusion6 decks42 decks
9%synergy
The Darkness Crystal
14%inclusion3 decks21 decks
-5%synergy
Brotherhood Regalia
13%inclusion5 decks39 decks
10%synergy
Manifold Key
12%inclusion5 decks42 decks
10%synergy
Prowler's Helm
12%inclusion5 decks42 decks
11%synergy
Sword of Truth and Justice
12%inclusion5 decks42 decks
11%synergy
Shadowspear
12%inclusion5 decks42 decks
8%synergy
Sword of the Animist
12%inclusion5 decks42 decks
8%synergy
Thran Power Suit
10%inclusion4 decks42 decks
9%synergy
Bontu's Monument
10%inclusion4 decks42 decks
-18%synergy
Livewire Lash
10%inclusion4 decks42 decks
9%synergy
Silver Shroud Costume
10%inclusion4 decks42 decks
8%synergy
Darksteel Plate
10%inclusion4 decks42 decks
8%synergy
Pact Weapon
10%inclusion4 decks42 decks
7%synergy
Hammer of Nazahn
10%inclusion4 decks42 decks
9%synergy
Basilisk Collar
10%inclusion4 decks42 decks
7%synergy
Genji Glove
10%inclusion2 decks21 decks
8%synergy
Bloodthorn Flail
7.1%inclusion3 decks42 decks
7%synergy
Viridian Claw
7.1%inclusion3 decks42 decks
7%synergy
Pip-Boy 3000
7.1%inclusion3 decks42 decks
7%synergy
O-Naginata
7.1%inclusion3 decks42 decks
7%synergy
Vorpal Sword
7.1%inclusion3 decks42 decks
3%synergy
Armillary Sphere
7.1%inclusion3 decks42 decks
7%synergy
Sword of the Chosen
7.1%inclusion3 decks42 decks
7%synergy
Whip of Erebos
7.1%inclusion3 decks42 decks
-4%synergy
Mind Carver
7.1%inclusion3 decks42 decks
7%synergy
Heirloom Blade
7.1%inclusion3 decks42 decks
7%synergy
Prosthetic Injector
7.1%inclusion3 decks42 decks
7%synergy
Strider Harness
7.1%inclusion3 decks42 decks
7%synergy
Ring of Xathrid
7.1%inclusion3 decks42 decks
6%synergy
Enchantments
Phyrexian Arena
48%inclusion20 decks42 decks
7%synergy
Necrogen Communion
38%inclusion16 decks42 decks
36%synergy
Kaya's Ghostform
33%inclusion14 decks42 decks
23%synergy
Unspeakable Symbol
26%inclusion11 decks42 decks
25%synergy
Bad Moon
21%inclusion9 decks42 decks
18%synergy
Fungal Fortitude
19%inclusion8 decks42 decks
18%synergy
Phyresis
17%inclusion7 decks42 decks
15%synergy
Relic Putrescence
14%inclusion6 decks42 decks
14%synergy
Greed
10%inclusion4 decks42 decks
2%synergy
Glistening Oil
10%inclusion4 decks42 decks
9%synergy
Dauthi Embrace
10%inclusion4 decks42 decks
8%synergy
Endless Scream
10%inclusion4 decks42 decks
9%synergy
Demonic Embrace
10%inclusion4 decks42 decks
9%synergy
Black Market Connections
10%inclusion4 decks42 decks
-14%synergy
Demonic Vigor
7.1%inclusion3 decks42 decks
7%synergy
Phyrexian Scriptures
7.1%inclusion3 decks42 decks
6%synergy
Black Market
7.1%inclusion3 decks42 decks
-14%synergy
Underworld Connections
7.1%inclusion3 decks42 decks
5%synergy
No Mercy
7.1%inclusion3 decks42 decks
0%synergy
Shade's Form
7.1%inclusion3 decks42 decks
6%synergy
Eternal Thirst
7.1%inclusion3 decks42 decks
5%synergy
Alien Symbiosis
7.1%inclusion1 decks14 decks
7%synergy
Super State
5.6%inclusion1 decks18 decks
5%synergy
Planeswalkers
Vraska, Betrayal's Sting
31%inclusion13 decks42 decks
28%synergy
Liliana of the Dark Realms
21%inclusion9 decks42 decks
7%synergy
Utility Lands
Rogue's Passage
57%inclusion24 decks42 decks
38%synergy
Karn's Bastion
50%inclusion21 decks42 decks
46%synergy
Cabal Coffers
45%inclusion19 decks42 decks
-10%synergy
Bojuka Bog
38%inclusion16 decks42 decks
-9%synergy
Inkmoth Nexus
36%inclusion15 decks42 decks
35%synergy
Cabal Stronghold
31%inclusion13 decks42 decks
-4%synergy
Cathedral of War
29%inclusion12 decks42 decks
28%synergy
Shizo, Death's Storehouse
24%inclusion10 decks42 decks
14%synergy
War Room
19%inclusion8 decks42 decks
3%synergy
Urborg, Tomb of Yawgmoth
19%inclusion8 decks42 decks
-19%synergy
Barren Moor
17%inclusion7 decks42 decks
6%synergy
Nykthos, Shrine to Nyx
17%inclusion7 decks42 decks
-13%synergy
Witch's Cottage
17%inclusion7 decks42 decks
-8%synergy
Command Beacon
14%inclusion6 decks42 decks
6%synergy
Castle Locthwain
14%inclusion6 decks42 decks
-3%synergy
Mortuary Mire
12%inclusion5 decks42 decks
-1%synergy
Phyrexian Tower
10%inclusion4 decks42 decks
-15%synergy
Secret Tunnel
8.3%inclusion1 decks12 decks
7%synergy
Buried Ruin
7.1%inclusion3 decks42 decks
2%synergy
The Dross Pits
7.1%inclusion3 decks42 decks
6%synergy
The Black Gate
7.1%inclusion3 decks42 decks
4%synergy
Polluted Mire
7.1%inclusion3 decks42 decks
3%synergy
Temple of the False God
7.1%inclusion3 decks42 decks
-1%synergy
Spawning Pool
7.1%inclusion3 decks42 decks
7%synergy
Mana Artifacts
Sol Ring
86%inclusion36 decks42 decks
0%synergy
Arcane Signet
64%inclusion27 decks42 decks
2%synergy
Charcoal Diamond
40%inclusion17 decks42 decks
17%synergy
Glistening Sphere
36%inclusion15 decks42 decks
34%synergy
Heraldic Banner
26%inclusion11 decks42 decks
21%synergy
Mind Stone
26%inclusion11 decks42 decks
-4%synergy
Staff of Compleation
24%inclusion10 decks42 decks
22%synergy
Caged Sun
21%inclusion9 decks42 decks
9%synergy
Fellwar Stone
14%inclusion6 decks42 decks
0%synergy
Thought Vessel
12%inclusion5 decks42 decks
-15%synergy
Worn Powerstone
12%inclusion5 decks42 decks
8%synergy
Commander's Sphere
10%inclusion4 decks42 decks
0%synergy
Hedron Archive
10%inclusion4 decks42 decks
6%synergy
Throne of Eldraine
10%inclusion4 decks42 decks
-1%synergy
Everflowing Chalice
7.1%inclusion3 decks42 decks
1%synergy
Gilded Lotus
7.1%inclusion3 decks42 decks
2%synergy
The Soul Stone
6.3%inclusion1 decks16 decks
-7%synergy
Lands
Swamp
100%inclusion42 decks42 decks
5%synergy
Myriad Landscape
33%inclusion14 decks42 decks
7%synergy
Mirrex
21%inclusion9 decks42 decks
21%synergy
Malakir Rebirth
21%inclusion9 decks42 decks
-1%synergy
Fell the Profane
10%inclusion4 decks39 decks
-9%synergy
Opal Palace
10%inclusion4 decks42 decks
9%synergy
The Seedcore
7.1%inclusion3 decks42 decks
7%synergy
Daily Bugle Building
7.1%inclusion1 decks14 decks
7%synergy
Urza's Cave
5.1%inclusion2 decks39 decks
-3%synergy
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