Skithiryx, the Blight Dragon (Commander) - Optimized Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #792
26decks
As CommanderAs CardAverage DeckDecks
Bracket
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Budget
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Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Utility Artifacts
Enchantments
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Utility Lands
Mana Artifacts
Lands
Back to Top
Plague Stinger
69%inclusion18 decks26 decks
68%synergy
Karn's Bastion
65%inclusion17 decks26 decks
62%synergy
Whispering Specter
58%inclusion15 decks26 decks
57%synergy
Plague Myr
58%inclusion15 decks26 decks
56%synergy
Phyresis Outbreak
58%inclusion15 decks26 decks
56%synergy
Deadly Rollick
81%inclusion21 decks26 decks
56%synergy
Ichor Rats
58%inclusion15 decks26 decks
55%synergy
Hand of the Praetors
54%inclusion14 decks26 decks
53%synergy
Phyrexian Crusader
54%inclusion14 decks26 decks
53%synergy
Shizo, Death's Storehouse
62%inclusion16 decks26 decks
51%synergy
Top Cards
Dark Ritual
92%inclusion24 decks26 decks
25%synergy
Jet Medallion
81%inclusion21 decks26 decks
19%synergy
Crypt Ghast
65%inclusion17 decks26 decks
18%synergy
Toxic Deluge
65%inclusion17 decks26 decks
29%synergy
Damnation
58%inclusion15 decks26 decks
37%synergy
Phyrexian Arena
58%inclusion15 decks26 decks
18%synergy
Lashwrithe
54%inclusion14 decks26 decks
50%synergy
Vraska's Fall
54%inclusion14 decks26 decks
51%synergy
Cabal Ritual
54%inclusion14 decks26 decks
35%synergy
Swiftfoot Boots
54%inclusion14 decks26 decks
22%synergy
Game Changers
Demonic Tutor
81%inclusion21 decks26 decks
54%synergy
Vampiric Tutor
73%inclusion19 decks26 decks
52%synergy
Ancient Tomb
58%inclusion15 decks26 decks
46%synergy
Necropotence
58%inclusion15 decks26 decks
43%synergy
Opposition Agent
50%inclusion13 decks26 decks
40%synergy
Mana Vault
42%inclusion11 decks26 decks
36%synergy
Imperial Seal
38%inclusion10 decks26 decks
32%synergy
Chrome Mox
38%inclusion10 decks26 decks
32%synergy
The One Ring
35%inclusion9 decks26 decks
25%synergy
Orcish Bowmasters
35%inclusion9 decks26 decks
22%synergy
Creatures
Sheoldred, the Apocalypse
46%inclusion12 decks26 decks
32%synergy
Dauthi Voidwalker
42%inclusion11 decks26 decks
27%synergy
Yawgmoth, Thran Physician
38%inclusion10 decks26 decks
28%synergy
Phyrexian Obliterator
35%inclusion9 decks26 decks
23%synergy
K'rrik, Son of Yawgmoth
35%inclusion9 decks26 decks
15%synergy
Ichorclaw Myr
31%inclusion8 decks26 decks
30%synergy
Blightbelly Rat
31%inclusion8 decks26 decks
27%synergy
Pestilent Syphoner
27%inclusion7 decks26 decks
26%synergy
Dark Confidant
27%inclusion7 decks26 decks
19%synergy
Reaper of Sheoldred
27%inclusion7 decks26 decks
26%synergy
Flensermite
27%inclusion7 decks26 decks
26%synergy
Gray Merchant of Asphodel
23%inclusion6 decks26 decks
-28%synergy
Bilious Skulldweller
19%inclusion5 decks26 decks
18%synergy
Flesh-Eater Imp
19%inclusion5 decks26 decks
19%synergy
Sheoldred, Whispering One
15%inclusion4 decks26 decks
4%synergy
Septic Rats
15%inclusion4 decks26 decks
14%synergy
Necropede
15%inclusion4 decks26 decks
15%synergy
Blightsteel Colossus
15%inclusion4 decks26 decks
15%synergy
Emeritus of Woe
13%inclusion1 decks8 decks
5%synergy
Phyrexian Juggernaut
12%inclusion3 decks26 decks
11%synergy
Contagious Nim
12%inclusion3 decks26 decks
11%synergy
Core Prowler
12%inclusion3 decks26 decks
11%synergy
Maha, Its Feathers Night
12%inclusion3 decks26 decks
7%synergy
Necroskitter
12%inclusion3 decks26 decks
9%synergy
Myr Convert
12%inclusion3 decks26 decks
11%synergy
Nirkana Revenant
12%inclusion3 decks26 decks
1%synergy
Vito, Thorn of the Dusk Rose
12%inclusion3 decks26 decks
1%synergy
Corpse Cur
12%inclusion3 decks26 decks
11%synergy
Nimraiser Paladin
12%inclusion3 decks26 decks
11%synergy
Scheming Aspirant
12%inclusion3 decks26 decks
11%synergy
Grave Researcher
11%inclusion1 decks9 decks
3%synergy
Bitterbloom Bearer
11%inclusion2 decks19 decks
4%synergy
Gwenom, Remorseless
10%inclusion2 decks21 decks
6%synergy
Madame Null, Power Broker
8.3%inclusion1 decks12 decks
7%synergy
Solemn Simulacrum
7.7%inclusion2 decks26 decks
-14%synergy
Blackcleave Goblin
7.7%inclusion2 decks26 decks
7%synergy
Lobelia Sackville-Baggins
7.7%inclusion2 decks26 decks
7%synergy
Rottenmouth Viper
7.7%inclusion2 decks26 decks
4%synergy
Plaguecrafter
7.7%inclusion2 decks26 decks
-12%synergy
Nightmare
7.7%inclusion2 decks26 decks
7%synergy
Ornithopter of Paradise
7.7%inclusion2 decks26 decks
5%synergy
Bloodletter of Aclazotz
7.7%inclusion2 decks26 decks
-3%synergy
Swamp Mosquito
7.7%inclusion2 decks26 decks
8%synergy
Gix, Yawgmoth Praetor
7.7%inclusion2 decks26 decks
3%synergy
Massacre Wurm
7.7%inclusion2 decks26 decks
-9%synergy
Sheoldred's Headcleaver
7.7%inclusion2 decks26 decks
7%synergy
Bonepicker Skirge
7.7%inclusion2 decks26 decks
8%synergy
Accursed Marauder
7.7%inclusion2 decks26 decks
-14%synergy
Gulping Scraptrap
7.7%inclusion2 decks26 decks
7%synergy
Midnight Banshee
7.7%inclusion2 decks26 decks
5%synergy
Instants
Howl from Beyond
50%inclusion13 decks26 decks
49%synergy
Go for the Throat
42%inclusion11 decks26 decks
20%synergy
Imp's Mischief
42%inclusion11 decks26 decks
17%synergy
Hatred
38%inclusion10 decks26 decks
37%synergy
Dismember
38%inclusion10 decks26 decks
28%synergy
Snuff Out
31%inclusion8 decks26 decks
17%synergy
Infernal Grasp
31%inclusion8 decks26 decks
6%synergy
Tainted Strike
31%inclusion8 decks26 decks
28%synergy
Withering Torment
31%inclusion8 decks26 decks
-1%synergy
Whisper of the Dross
27%inclusion7 decks26 decks
24%synergy
Darkness
27%inclusion7 decks26 decks
17%synergy
Sudden Spoiling
27%inclusion7 decks26 decks
18%synergy
Sheoldred's Edict
23%inclusion6 decks26 decks
8%synergy
Hero's Downfall
19%inclusion5 decks26 decks
13%synergy
Fell the Profane
19%inclusion5 decks26 decks
-0%synergy
Withering Boon
19%inclusion5 decks26 decks
15%synergy
Malakir Rebirth
19%inclusion5 decks26 decks
-4%synergy
Astarion's Thirst
15%inclusion4 decks26 decks
14%synergy
Cut Down
15%inclusion4 decks26 decks
12%synergy
Defile
15%inclusion4 decks26 decks
-20%synergy
Culling the Weak
15%inclusion4 decks26 decks
-2%synergy
Slaughter Pact
15%inclusion4 decks26 decks
13%synergy
Force of Despair
12%inclusion3 decks26 decks
4%synergy
Doom Blade
12%inclusion3 decks26 decks
4%synergy
Soul Shatter
12%inclusion3 decks26 decks
-0%synergy
Bitter Triumph
12%inclusion3 decks26 decks
2%synergy
Archenemy's Charm
10%inclusion2 decks21 decks
1%synergy
Anoint with Affliction
7.7%inclusion2 decks26 decks
7%synergy
Grim Affliction
7.7%inclusion2 decks26 decks
6%synergy
Virulent Wound
7.7%inclusion2 decks26 decks
7%synergy
Rush of Vitality
7.7%inclusion2 decks26 decks
7%synergy
Murder
7.7%inclusion2 decks26 decks
-2%synergy
Ad Nauseam
7.7%inclusion2 decks26 decks
5%synergy
Fake Your Own Death
7.7%inclusion2 decks26 decks
0%synergy
Baleful Mastery
7.7%inclusion2 decks26 decks
-0%synergy
Black Sun's Twilight
7.7%inclusion2 decks26 decks
4%synergy
Offer Immortality
7.7%inclusion2 decks26 decks
6%synergy
Liliana's Triumph
7.7%inclusion2 decks26 decks
2%synergy
Abnormal Endurance
7.7%inclusion2 decks26 decks
7%synergy
Blight Rot
7.7%inclusion1 decks13 decks
7%synergy
Sorceries
Infectious Inquiry
50%inclusion13 decks26 decks
47%synergy
Night's Whisper
46%inclusion12 decks26 decks
21%synergy
Grim Tutor
46%inclusion12 decks26 decks
35%synergy
Feed the Swarm
42%inclusion11 decks26 decks
-8%synergy
Sign in Blood
42%inclusion11 decks26 decks
7%synergy
Drown in Ichor
42%inclusion11 decks26 decks
39%synergy
Bubbling Muck
38%inclusion10 decks26 decks
23%synergy
Crux of Fate
38%inclusion10 decks26 decks
37%synergy
Reanimate
31%inclusion8 decks26 decks
-9%synergy
Blasphemous Edict
28%inclusion7 decks25 decks
12%synergy
Caress of Phyrexia
27%inclusion7 decks26 decks
26%synergy
Vat Emergence
19%inclusion5 decks26 decks
18%synergy
Diabolic Tutor
19%inclusion5 decks26 decks
5%synergy
Torment of Hailfire
19%inclusion5 decks26 decks
4%synergy
Exsanguinate
19%inclusion5 decks26 decks
-5%synergy
Black Sun's Zenith
15%inclusion4 decks26 decks
10%synergy
Profane Tutor
15%inclusion4 decks26 decks
11%synergy
Yawgmoth's Will
15%inclusion4 decks26 decks
12%synergy
Duress
15%inclusion4 decks26 decks
9%synergy
Praetor's Grasp
15%inclusion4 decks26 decks
12%synergy
Insatiable Avarice
15%inclusion4 decks26 decks
4%synergy
Pox Plague
13%inclusion1 decks8 decks
7%synergy
Diabolic Intent
12%inclusion3 decks26 decks
-3%synergy
Read the Bones
12%inclusion3 decks26 decks
-5%synergy
Mutilate
12%inclusion3 decks26 decks
-5%synergy
Beseech the Mirror
12%inclusion3 decks26 decks
5%synergy
Thoughtseize
12%inclusion3 decks26 decks
7%synergy
Splinter's Technique
8.3%inclusion1 decks12 decks
6%synergy
Victimize
7.7%inclusion2 decks26 decks
-19%synergy
Dreams of Steel and Oil
7.7%inclusion2 decks26 decks
8%synergy
Utility Artifacts
Lightning Greaves
50%inclusion13 decks26 decks
16%synergy
Blackblade Reforged
50%inclusion13 decks26 decks
47%synergy
Shadowspear
46%inclusion12 decks26 decks
42%synergy
Commander's Plate
46%inclusion12 decks26 decks
40%synergy
Nightmare Lash
42%inclusion11 decks26 decks
40%synergy
Sword of Truth and Justice
35%inclusion9 decks26 decks
34%synergy
Whispersilk Cloak
35%inclusion9 decks26 decks
29%synergy
Bolas's Citadel
31%inclusion8 decks26 decks
2%synergy
Fireshrieker
31%inclusion8 decks26 decks
29%synergy
Mithril Coat
27%inclusion7 decks26 decks
21%synergy
Contagion Engine
27%inclusion7 decks26 decks
25%synergy
Champion's Helm
27%inclusion7 decks26 decks
25%synergy
Sensei's Divining Top
23%inclusion6 decks26 decks
15%synergy
Contagion Clasp
23%inclusion6 decks26 decks
21%synergy
The Darkness Crystal
23%inclusion5 decks22 decks
3%synergy
Expedition Map
19%inclusion5 decks26 decks
8%synergy
Trailblazer's Boots
15%inclusion4 decks26 decks
13%synergy
Wishclaw Talisman
15%inclusion4 decks26 decks
8%synergy
Conqueror's Flail
15%inclusion4 decks26 decks
15%synergy
Winter Moon
15%inclusion4 decks26 decks
14%synergy
Doc Ock's Tentacles
15%inclusion3 decks20 decks
15%synergy
Genji Glove
14%inclusion3 decks22 decks
12%synergy
Leyline Axe
12%inclusion3 decks25 decks
11%synergy
Defense Grid
12%inclusion3 decks26 decks
9%synergy
Skullclamp
12%inclusion3 decks26 decks
-11%synergy
Cranial Plating
12%inclusion3 decks26 decks
8%synergy
Silver Shroud Costume
12%inclusion3 decks26 decks
10%synergy
Sword of Feast and Famine
12%inclusion3 decks26 decks
10%synergy
Loxodon Warhammer
12%inclusion3 decks26 decks
10%synergy
Hammer of Nazahn
12%inclusion3 decks26 decks
11%synergy
Basilisk Collar
12%inclusion3 decks26 decks
9%synergy
Vat of Rebirth
7.7%inclusion2 decks26 decks
4%synergy
Helm of Obedience
7.7%inclusion2 decks26 decks
7%synergy
Thran Power Suit
7.7%inclusion2 decks26 decks
7%synergy
Whip of Erebos
7.7%inclusion2 decks26 decks
-3%synergy
Sword of Hearth and Home
7.7%inclusion2 decks26 decks
6%synergy
Bontu's Monument
7.7%inclusion2 decks26 decks
-21%synergy
Sword of Wealth and Power
7.7%inclusion2 decks26 decks
7%synergy
Pact Weapon
7.7%inclusion2 decks26 decks
6%synergy
Brotherhood Regalia
7.7%inclusion2 decks26 decks
5%synergy
Sword of the Animist
7.7%inclusion2 decks26 decks
4%synergy
Isochron Scepter
7.7%inclusion2 decks26 decks
7%synergy
Sword of Vengeance
7.7%inclusion2 decks26 decks
7%synergy
Hero's Blade
7.7%inclusion2 decks26 decks
7%synergy
Enchantments
Unspeakable Symbol
42%inclusion11 decks26 decks
41%synergy
Black Market Connections
38%inclusion10 decks26 decks
14%synergy
Necrogen Communion
31%inclusion8 decks26 decks
29%synergy
No Mercy
27%inclusion7 decks26 decks
20%synergy
Contamination
23%inclusion6 decks26 decks
20%synergy
Phyresis
23%inclusion6 decks26 decks
21%synergy
Leyline of the Void
19%inclusion5 decks26 decks
17%synergy
Super State
18%inclusion4 decks22 decks
18%synergy
The Meathook Massacre
15%inclusion4 decks26 decks
-2%synergy
Glistening Oil
12%inclusion3 decks26 decks
11%synergy
Exquisite Blood
12%inclusion3 decks26 decks
-2%synergy
Kaya's Ghostform
12%inclusion3 decks26 decks
2%synergy
Infernal Darkness
12%inclusion3 decks26 decks
11%synergy
Bitterblossom
12%inclusion3 decks26 decks
-2%synergy
Nest of Scarabs
7.7%inclusion2 decks26 decks
4%synergy
Grievous Wound
7.7%inclusion2 decks26 decks
5%synergy
Phyrexian Reclamation
7.7%inclusion2 decks26 decks
-2%synergy
Haunted One
7.7%inclusion2 decks26 decks
5%synergy
Grave Pact
7.7%inclusion2 decks26 decks
-12%synergy
Sanguine Bond
7.7%inclusion2 decks26 decks
-4%synergy
Wound Reflection
7.7%inclusion2 decks26 decks
4%synergy
Dauthi Embrace
7.7%inclusion2 decks26 decks
6%synergy
Snake Cult Initiation
7.7%inclusion2 decks26 decks
8%synergy
Animate Dead
7.7%inclusion2 decks26 decks
-10%synergy
Oubliette
7.7%inclusion2 decks26 decks
5%synergy
Fungal Fortitude
7.7%inclusion2 decks26 decks
6%synergy
Demonic Embrace
7.7%inclusion2 decks26 decks
7%synergy
Mornsong Aria
7.7%inclusion1 decks13 decks
6%synergy
Planeswalkers
Liliana of the Dark Realms
50%inclusion13 decks26 decks
36%synergy
Vraska, Betrayal's Sting
46%inclusion12 decks26 decks
44%synergy
Liliana of the Veil
12%inclusion3 decks26 decks
5%synergy
Utility Lands
Urborg, Tomb of Yawgmoth
73%inclusion19 decks26 decks
35%synergy
Cabal Coffers
69%inclusion18 decks26 decks
14%synergy
Rogue's Passage
69%inclusion18 decks26 decks
50%synergy
Inkmoth Nexus
50%inclusion13 decks26 decks
49%synergy
Nykthos, Shrine to Nyx
42%inclusion11 decks26 decks
13%synergy
Bojuka Bog
27%inclusion7 decks26 decks
-20%synergy
Cabal Stronghold
27%inclusion7 decks26 decks
-7%synergy
Urza's Saga
27%inclusion7 decks26 decks
19%synergy
Reliquary Tower
27%inclusion7 decks26 decks
-3%synergy
Deserted Temple
23%inclusion6 decks26 decks
19%synergy
Takenuma, Abandoned Mire
23%inclusion6 decks26 decks
7%synergy
Lake of the Dead
23%inclusion6 decks26 decks
18%synergy
Temple of the False God
19%inclusion5 decks26 decks
12%synergy
Strip Mine
19%inclusion5 decks26 decks
16%synergy
Homeward Path
15%inclusion4 decks26 decks
14%synergy
Phyrexian Tower
12%inclusion3 decks26 decks
-14%synergy
The Black Gate
12%inclusion3 decks26 decks
8%synergy
Cathedral of War
12%inclusion3 decks26 decks
11%synergy
War Room
12%inclusion3 decks26 decks
-4%synergy
Command Beacon
12%inclusion3 decks26 decks
3%synergy
Minas Morgul, Dark Fortress
12%inclusion3 decks26 decks
9%synergy
Thespian's Stage
12%inclusion3 decks26 decks
6%synergy
Castle Locthwain
12%inclusion3 decks26 decks
-5%synergy
Vault of Whispers
7.7%inclusion2 decks26 decks
2%synergy
Wasteland
7.7%inclusion2 decks26 decks
6%synergy
Arcane Lighthouse
7.7%inclusion2 decks26 decks
6%synergy
Maze of Ith
7.7%inclusion2 decks26 decks
5%synergy
Emergence Zone
7.7%inclusion2 decks26 decks
4%synergy
High Market
7.7%inclusion2 decks26 decks
0%synergy
Urborg
7.7%inclusion2 decks26 decks
7%synergy
Dark Depths
7.7%inclusion2 decks26 decks
7%synergy
Hive of the Eye Tyrant
7.7%inclusion2 decks26 decks
7%synergy
Mana Artifacts
Sol Ring
96%inclusion25 decks26 decks
11%synergy
Arcane Signet
54%inclusion14 decks26 decks
-8%synergy
Lotus Petal
38%inclusion10 decks26 decks
31%synergy
The Soul Stone
33%inclusion7 decks21 decks
18%synergy
Glistening Sphere
31%inclusion8 decks26 decks
30%synergy
Staff of Compleation
27%inclusion7 decks26 decks
25%synergy
Mox Amber
27%inclusion7 decks26 decks
23%synergy
Mox Opal
27%inclusion7 decks26 decks
23%synergy
Fellwar Stone
23%inclusion6 decks26 decks
9%synergy
Mind Stone
23%inclusion6 decks26 decks
-5%synergy
Gilded Lotus
15%inclusion4 decks26 decks
10%synergy
Mox Diamond
15%inclusion4 decks26 decks
12%synergy
Caged Sun
12%inclusion3 decks26 decks
1%synergy
Charcoal Diamond
12%inclusion3 decks26 decks
-10%synergy
Grim Monolith
12%inclusion3 decks26 decks
9%synergy
Heraldic Banner
12%inclusion3 decks26 decks
6%synergy
Throne of Eldraine
12%inclusion3 decks26 decks
2%synergy
Thought Vessel
12%inclusion3 decks26 decks
-14%synergy
Mox Jasper
8.3%inclusion2 decks24 decks
8%synergy
Thran Dynamo
7.7%inclusion2 decks26 decks
2%synergy
Extraplanar Lens
7.7%inclusion2 decks26 decks
3%synergy
Wickersmith's Tools
7.7%inclusion1 decks13 decks
8%synergy
Lands
Swamp
96%inclusion25 decks26 decks
1%synergy
Cavern of Souls
46%inclusion12 decks26 decks
39%synergy
Verdant Catacombs
23%inclusion6 decks26 decks
20%synergy
Bloodstained Mire
23%inclusion6 decks26 decks
19%synergy
Fell the Profane
19%inclusion5 decks26 decks
-0%synergy
Malakir Rebirth
19%inclusion5 decks26 decks
-4%synergy
Marsh Flats
19%inclusion5 decks26 decks
16%synergy
Polluted Delta
19%inclusion5 decks26 decks
16%synergy
Myriad Landscape
15%inclusion4 decks26 decks
-10%synergy
Gemstone Caverns
15%inclusion4 decks26 decks
11%synergy
Mirrex
12%inclusion3 decks26 decks
11%synergy
Command Tower
7.7%inclusion2 decks26 decks
2%synergy
Fabled Passage
7.7%inclusion2 decks26 decks
6%synergy
Snow-Covered Swamp
7.7%inclusion2 decks26 decks
1%synergy
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