Skithiryx, the Blight Dragon (Commander) - Optimized Infect

Alternate Names:

Venom, King in BlackVenom, King in Black

Skithiryx, the Blight Dragon
Rank #780
25decks
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Background image for The Top 10 Most Played 4-Color Cards in Commander
Nick Price
Dec 17, 2025
Nick Price
The Top 10 Most Played 4-Color Cards in Commander
Which 4-color cards are the most played in Commander? Unsurprisingly, the list is full of powerful, and popular, legendary creatures.
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Utility Lands
Mana Artifacts
Lands
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Splinter's Technique
33%inclusion1 decks3 decks
33%synergy
Bitterbloom Bearer
6.3%inclusion1 decks16 decks
2%synergy
High Synergy Cards
Whispering Specter
72%inclusion18 decks25 decks
71%synergy
Plague Stinger
72%inclusion18 decks25 decks
71%synergy
Shizo, Death's Storehouse
72%inclusion18 decks25 decks
62%synergy
Plague Myr
60%inclusion15 decks25 decks
59%synergy
Vraska's Fall
60%inclusion15 decks25 decks
56%synergy
Commander's Plate
60%inclusion15 decks25 decks
54%synergy
Phyresis Outbreak
56%inclusion14 decks25 decks
54%synergy
Blackblade Reforged
56%inclusion14 decks25 decks
53%synergy
Infectious Inquiry
56%inclusion14 decks25 decks
53%synergy
Deadly Rollick
76%inclusion19 decks25 decks
52%synergy
Top Cards
Dark Ritual
92%inclusion23 decks25 decks
25%synergy
Jet Medallion
88%inclusion22 decks25 decks
27%synergy
Crypt Ghast
72%inclusion18 decks25 decks
24%synergy
Cabal Ritual
64%inclusion16 decks25 decks
46%synergy
Toxic Deluge
60%inclusion15 decks25 decks
23%synergy
Feed the Swarm
56%inclusion14 decks25 decks
5%synergy
Damnation
56%inclusion14 decks25 decks
35%synergy
Lashwrithe
52%inclusion13 decks25 decks
48%synergy
Howl from Beyond
52%inclusion13 decks25 decks
51%synergy
Shadowspear
52%inclusion13 decks25 decks
48%synergy
Game Changers
Demonic Tutor
88%inclusion22 decks25 decks
60%synergy
Vampiric Tutor
84%inclusion21 decks25 decks
63%synergy
Ancient Tomb
72%inclusion18 decks25 decks
60%synergy
Mana Vault
60%inclusion15 decks25 decks
53%synergy
Necropotence
60%inclusion15 decks25 decks
45%synergy
Chrome Mox
56%inclusion14 decks25 decks
50%synergy
Imperial Seal
48%inclusion12 decks25 decks
41%synergy
Opposition Agent
48%inclusion12 decks25 decks
38%synergy
The One Ring
48%inclusion12 decks25 decks
38%synergy
Orcish Bowmasters
40%inclusion10 decks25 decks
26%synergy
Creatures
Phyrexian Crusader
48%inclusion12 decks25 decks
47%synergy
Hand of the Praetors
48%inclusion12 decks25 decks
47%synergy
Ichor Rats
48%inclusion12 decks25 decks
45%synergy
Dauthi Voidwalker
44%inclusion11 decks25 decks
28%synergy
Sheoldred, the Apocalypse
40%inclusion10 decks25 decks
25%synergy
K'rrik, Son of Yawgmoth
36%inclusion9 decks25 decks
17%synergy
Phyrexian Obliterator
32%inclusion8 decks25 decks
21%synergy
Yawgmoth, Thran Physician
32%inclusion8 decks25 decks
22%synergy
Pestilent Syphoner
24%inclusion6 decks25 decks
23%synergy
Dark Confidant
24%inclusion6 decks25 decks
17%synergy
Reaper of Sheoldred
24%inclusion6 decks25 decks
23%synergy
Flensermite
24%inclusion6 decks25 decks
23%synergy
Ichorclaw Myr
24%inclusion6 decks25 decks
23%synergy
Blightbelly Rat
24%inclusion6 decks25 decks
20%synergy
Gray Merchant of Asphodel
20%inclusion5 decks25 decks
-32%synergy
Flesh-Eater Imp
20%inclusion5 decks25 decks
19%synergy
Myr Convert
16%inclusion4 decks25 decks
15%synergy
Bilious Skulldweller
16%inclusion4 decks25 decks
15%synergy
Blightsteel Colossus
16%inclusion4 decks25 decks
15%synergy
Contagious Nim
12%inclusion3 decks25 decks
12%synergy
Nirkana Revenant
12%inclusion3 decks25 decks
1%synergy
Vito, Thorn of the Dusk Rose
12%inclusion3 decks25 decks
1%synergy
Corpse Cur
12%inclusion3 decks25 decks
12%synergy
Sheoldred, Whispering One
12%inclusion3 decks25 decks
0%synergy
Septic Rats
12%inclusion3 decks25 decks
10%synergy
Necropede
12%inclusion3 decks25 decks
12%synergy
Solemn Simulacrum
8.0%inclusion2 decks25 decks
-15%synergy
Core Prowler
8.0%inclusion2 decks25 decks
7%synergy
Maha, Its Feathers Night
8.0%inclusion2 decks25 decks
3%synergy
Blackcleave Goblin
8.0%inclusion2 decks25 decks
8%synergy
Lobelia Sackville-Baggins
8.0%inclusion2 decks25 decks
7%synergy
Bloodletter of Aclazotz
8.0%inclusion2 decks25 decks
-3%synergy
Swamp Mosquito
8.0%inclusion2 decks25 decks
8%synergy
Necroskitter
8.0%inclusion2 decks25 decks
5%synergy
Massacre Wurm
8.0%inclusion2 decks25 decks
-9%synergy
Metalworker
8.0%inclusion2 decks25 decks
8%synergy
Sheoldred's Headcleaver
8.0%inclusion2 decks25 decks
8%synergy
Nimraiser Paladin
8.0%inclusion2 decks25 decks
8%synergy
Scheming Aspirant
8.0%inclusion2 decks25 decks
8%synergy
Gulping Scraptrap
8.0%inclusion2 decks25 decks
7%synergy
Blood Pet
8.0%inclusion2 decks25 decks
0%synergy
Leaden Myr
8.0%inclusion2 decks25 decks
2%synergy
Agent Venom
5.6%inclusion1 decks18 decks
3%synergy
Surge Conductor
5.3%inclusion1 decks19 decks
5%synergy
Instants
Imp's Mischief
44%inclusion11 decks25 decks
20%synergy
Dismember
44%inclusion11 decks25 decks
33%synergy
Go for the Throat
40%inclusion10 decks25 decks
17%synergy
Hatred
40%inclusion10 decks25 decks
39%synergy
Sudden Spoiling
32%inclusion8 decks25 decks
23%synergy
Whisper of the Dross
28%inclusion7 decks25 decks
25%synergy
Tainted Strike
28%inclusion7 decks25 decks
25%synergy
Withering Torment
28%inclusion7 decks25 decks
-4%synergy
Cut Down
24%inclusion6 decks25 decks
20%synergy
Snuff Out
24%inclusion6 decks25 decks
11%synergy
Darkness
24%inclusion6 decks25 decks
14%synergy
Astarion's Thirst
20%inclusion5 decks25 decks
19%synergy
Hero's Downfall
20%inclusion5 decks25 decks
13%synergy
Sheoldred's Edict
20%inclusion5 decks25 decks
6%synergy
Withering Boon
20%inclusion5 decks25 decks
16%synergy
Infernal Grasp
20%inclusion5 decks25 decks
-5%synergy
Fell the Profane
16%inclusion4 decks25 decks
-3%synergy
Culling the Weak
16%inclusion4 decks25 decks
1%synergy
Force of Despair
12%inclusion3 decks25 decks
4%synergy
Defile
12%inclusion3 decks25 decks
-25%synergy
Soul Shatter
12%inclusion3 decks25 decks
0%synergy
Slaughter Pact
12%inclusion3 decks25 decks
9%synergy
Bitter Triumph
12%inclusion3 decks25 decks
2%synergy
Murder
12%inclusion3 decks25 decks
2%synergy
Malakir Rebirth
12%inclusion3 decks25 decks
-11%synergy
Baleful Mastery
12%inclusion3 decks25 decks
3%synergy
Fatal Push
8.0%inclusion2 decks25 decks
5%synergy
Not Dead After All
8.0%inclusion2 decks25 decks
-3%synergy
Anoint with Affliction
8.0%inclusion2 decks25 decks
7%synergy
Grim Affliction
8.0%inclusion2 decks25 decks
6%synergy
Sugar Rush
8.0%inclusion2 decks25 decks
7%synergy
Doom Blade
8.0%inclusion2 decks25 decks
0%synergy
Virulent Wound
8.0%inclusion2 decks25 decks
8%synergy
Ad Nauseam
8.0%inclusion2 decks25 decks
5%synergy
Black Sun's Twilight
8.0%inclusion2 decks25 decks
4%synergy
Liliana's Triumph
8.0%inclusion2 decks25 decks
2%synergy
Archenemy's Charm
5.3%inclusion1 decks19 decks
-4%synergy
Sorceries
Drown in Ichor
52%inclusion13 decks25 decks
48%synergy
Grim Tutor
52%inclusion13 decks25 decks
40%synergy
Bubbling Muck
44%inclusion11 decks25 decks
28%synergy
Night's Whisper
44%inclusion11 decks25 decks
20%synergy
Crux of Fate
36%inclusion9 decks25 decks
35%synergy
Sign in Blood
36%inclusion9 decks25 decks
0%synergy
Reanimate
28%inclusion7 decks25 decks
-11%synergy
Blasphemous Edict
21%inclusion5 decks24 decks
4%synergy
Diabolic Tutor
20%inclusion5 decks25 decks
5%synergy
Torment of Hailfire
20%inclusion5 decks25 decks
4%synergy
Caress of Phyrexia
20%inclusion5 decks25 decks
19%synergy
Insatiable Avarice
20%inclusion5 decks25 decks
8%synergy
Beseech the Mirror
20%inclusion5 decks25 decks
13%synergy
Vat Emergence
16%inclusion4 decks25 decks
14%synergy
Profane Tutor
16%inclusion4 decks25 decks
12%synergy
Duress
16%inclusion4 decks25 decks
9%synergy
Praetor's Grasp
16%inclusion4 decks25 decks
12%synergy
Exsanguinate
16%inclusion4 decks25 decks
-8%synergy
Yawgmoth's Will
12%inclusion3 decks25 decks
9%synergy
Mutilate
12%inclusion3 decks25 decks
-6%synergy
Beseech the Queen
12%inclusion3 decks25 decks
6%synergy
Black Sun's Zenith
8.0%inclusion2 decks25 decks
2%synergy
Victimize
8.0%inclusion2 decks25 decks
-18%synergy
Inquisition of Kozilek
8.0%inclusion2 decks25 decks
6%synergy
Read the Bones
8.0%inclusion2 decks25 decks
-10%synergy
Dark Petition
8.0%inclusion2 decks25 decks
4%synergy
Dreams of Steel and Oil
8.0%inclusion2 decks25 decks
8%synergy
Thoughtseize
8.0%inclusion2 decks25 decks
3%synergy
Utility Artifacts
Nightmare Lash
48%inclusion12 decks25 decks
46%synergy
Lightning Greaves
44%inclusion11 decks25 decks
10%synergy
Swiftfoot Boots
44%inclusion11 decks25 decks
12%synergy
Sword of Truth and Justice
36%inclusion9 decks25 decks
35%synergy
Bolas's Citadel
32%inclusion8 decks25 decks
3%synergy
Whispersilk Cloak
32%inclusion8 decks25 decks
26%synergy
Champion's Helm
32%inclusion8 decks25 decks
30%synergy
The Darkness Crystal
29%inclusion6 decks21 decks
9%synergy
Mithril Coat
28%inclusion7 decks25 decks
22%synergy
Contagion Engine
28%inclusion7 decks25 decks
26%synergy
Sensei's Divining Top
24%inclusion6 decks25 decks
16%synergy
Wishclaw Talisman
24%inclusion6 decks25 decks
17%synergy
Expedition Map
20%inclusion5 decks25 decks
8%synergy
Conqueror's Flail
20%inclusion5 decks25 decks
19%synergy
Fireshrieker
20%inclusion5 decks25 decks
18%synergy
Hammer of Nazahn
20%inclusion5 decks25 decks
19%synergy
Leyline Axe
17%inclusion4 decks24 decks
16%synergy
Contagion Clasp
16%inclusion4 decks25 decks
13%synergy
Pact Weapon
16%inclusion4 decks25 decks
14%synergy
Sword of Wealth and Power
16%inclusion4 decks25 decks
15%synergy
Brotherhood Regalia
16%inclusion4 decks25 decks
14%synergy
Genji Glove
14%inclusion3 decks21 decks
13%synergy
Thran Power Suit
12%inclusion3 decks25 decks
12%synergy
Trailblazer's Boots
12%inclusion3 decks25 decks
10%synergy
Cranial Plating
12%inclusion3 decks25 decks
9%synergy
Silver Shroud Costume
12%inclusion3 decks25 decks
11%synergy
Sword of Feast and Famine
12%inclusion3 decks25 decks
10%synergy
Sword of the Animist
12%inclusion3 decks25 decks
8%synergy
Doc Ock's Tentacles
12%inclusion2 decks17 decks
12%synergy
Black Mage's Rod
10%inclusion2 decks21 decks
9%synergy
Buster Sword
10%inclusion2 decks21 decks
9%synergy
The Immortal Sun
8.0%inclusion2 decks25 decks
7%synergy
Aetherflux Reservoir
8.0%inclusion2 decks25 decks
-2%synergy
Lavaspur Boots
8.0%inclusion2 decks25 decks
6%synergy
Sword of Hearth and Home
8.0%inclusion2 decks25 decks
7%synergy
Bontu's Monument
8.0%inclusion2 decks25 decks
-20%synergy
Winter Moon
8.0%inclusion2 decks25 decks
6%synergy
Hero's Blade
8.0%inclusion2 decks25 decks
8%synergy
Isochron Scepter
8.0%inclusion2 decks25 decks
8%synergy
Sword of Vengeance
8.0%inclusion2 decks25 decks
7%synergy
Basilisk Collar
8.0%inclusion2 decks25 decks
5%synergy
Enchantments
Unspeakable Symbol
52%inclusion13 decks25 decks
51%synergy
Black Market Connections
48%inclusion12 decks25 decks
25%synergy
Phyrexian Arena
48%inclusion12 decks25 decks
8%synergy
Necrogen Communion
32%inclusion8 decks25 decks
30%synergy
No Mercy
24%inclusion6 decks25 decks
17%synergy
Super State
20%inclusion4 decks20 decks
20%synergy
The Meathook Massacre
16%inclusion4 decks25 decks
-1%synergy
Contamination
16%inclusion4 decks25 decks
13%synergy
Phyresis
16%inclusion4 decks25 decks
14%synergy
Phyrexian Reclamation
12%inclusion3 decks25 decks
2%synergy
Demonic Embrace
12%inclusion3 decks25 decks
11%synergy
Leyline of the Void
12%inclusion3 decks25 decks
10%synergy
Grievous Wound
8.0%inclusion2 decks25 decks
6%synergy
Haunted One
8.0%inclusion2 decks25 decks
5%synergy
Grave Pact
8.0%inclusion2 decks25 decks
-11%synergy
Exquisite Blood
8.0%inclusion2 decks25 decks
-5%synergy
Kaya's Ghostform
8.0%inclusion2 decks25 decks
-2%synergy
Wound Reflection
8.0%inclusion2 decks25 decks
5%synergy
Dauthi Embrace
8.0%inclusion2 decks25 decks
6%synergy
Snake Cult Initiation
8.0%inclusion2 decks25 decks
8%synergy
Oubliette
8.0%inclusion2 decks25 decks
5%synergy
Infernal Darkness
8.0%inclusion2 decks25 decks
7%synergy
Heartless Summoning
8.0%inclusion2 decks25 decks
3%synergy
Bitterblossom
8.0%inclusion2 decks25 decks
-5%synergy
Planeswalkers
Liliana of the Dark Realms
52%inclusion13 decks25 decks
38%synergy
Vraska, Betrayal's Sting
40%inclusion10 decks25 decks
37%synergy
Tezzeret, Cruel Captain
10%inclusion2 decks20 decks
9%synergy
Utility Lands
Urborg, Tomb of Yawgmoth
80%inclusion20 decks25 decks
42%synergy
Cabal Coffers
72%inclusion18 decks25 decks
17%synergy
Rogue's Passage
64%inclusion16 decks25 decks
45%synergy
Karn's Bastion
56%inclusion14 decks25 decks
52%synergy
Inkmoth Nexus
52%inclusion13 decks25 decks
51%synergy
Urza's Saga
40%inclusion10 decks25 decks
32%synergy
Cabal Stronghold
36%inclusion9 decks25 decks
1%synergy
Nykthos, Shrine to Nyx
36%inclusion9 decks25 decks
6%synergy
Bojuka Bog
32%inclusion8 decks25 decks
-15%synergy
Lake of the Dead
32%inclusion8 decks25 decks
27%synergy
Strip Mine
24%inclusion6 decks25 decks
21%synergy
The Black Gate
20%inclusion5 decks25 decks
17%synergy
Reliquary Tower
20%inclusion5 decks25 decks
-11%synergy
Cathedral of War
16%inclusion4 decks25 decks
16%synergy
Command Beacon
16%inclusion4 decks25 decks
8%synergy
Deserted Temple
16%inclusion4 decks25 decks
12%synergy
Takenuma, Abandoned Mire
16%inclusion4 decks25 decks
0%synergy
Temple of the False God
16%inclusion4 decks25 decks
8%synergy
Homeward Path
16%inclusion4 decks25 decks
14%synergy
Arcane Lighthouse
12%inclusion3 decks25 decks
10%synergy
Minas Morgul, Dark Fortress
12%inclusion3 decks25 decks
9%synergy
Vault of Whispers
8.0%inclusion2 decks25 decks
3%synergy
Wasteland
8.0%inclusion2 decks25 decks
7%synergy
Phyrexian Tower
8.0%inclusion2 decks25 decks
-16%synergy
Maze of Ith
8.0%inclusion2 decks25 decks
5%synergy
War Room
8.0%inclusion2 decks25 decks
-8%synergy
Emergence Zone
8.0%inclusion2 decks25 decks
5%synergy
Mishra's Workshop
8.0%inclusion2 decks25 decks
8%synergy
Castle Locthwain
8.0%inclusion2 decks25 decks
-9%synergy
Mana Artifacts
Sol Ring
96%inclusion24 decks25 decks
10%synergy
Arcane Signet
64%inclusion16 decks25 decks
2%synergy
Lotus Petal
48%inclusion12 decks25 decks
41%synergy
Mox Opal
44%inclusion11 decks25 decks
41%synergy
The Soul Stone
42%inclusion8 decks19 decks
29%synergy
Staff of Compleation
40%inclusion10 decks25 decks
38%synergy
Glistening Sphere
36%inclusion9 decks25 decks
35%synergy
Mox Amber
36%inclusion9 decks25 decks
32%synergy
Mox Diamond
28%inclusion7 decks25 decks
24%synergy
Fellwar Stone
24%inclusion6 decks25 decks
9%synergy
Mind Stone
24%inclusion6 decks25 decks
-6%synergy
Heraldic Banner
20%inclusion5 decks25 decks
14%synergy
Caged Sun
16%inclusion4 decks25 decks
4%synergy
Grim Monolith
16%inclusion4 decks25 decks
13%synergy
Throne of Eldraine
16%inclusion4 decks25 decks
6%synergy
Gilded Lotus
16%inclusion4 decks25 decks
10%synergy
Mox Jasper
13%inclusion3 decks23 decks
13%synergy
Charcoal Diamond
12%inclusion3 decks25 decks
-11%synergy
Thought Vessel
12%inclusion3 decks25 decks
-15%synergy
Extraplanar Lens
12%inclusion3 decks25 decks
7%synergy
Patchwork Banner
8.0%inclusion2 decks25 decks
4%synergy
Basalt Monolith
8.0%inclusion2 decks25 decks
6%synergy
Lands
Swamp
96%inclusion24 decks25 decks
1%synergy
Cavern of Souls
52%inclusion13 decks25 decks
45%synergy
Verdant Catacombs
32%inclusion8 decks25 decks
29%synergy
Bloodstained Mire
32%inclusion8 decks25 decks
28%synergy
Gemstone Caverns
28%inclusion7 decks25 decks
24%synergy
Marsh Flats
28%inclusion7 decks25 decks
25%synergy
Polluted Delta
28%inclusion7 decks25 decks
25%synergy
Fell the Profane
16%inclusion4 decks25 decks
-3%synergy
Command Tower
12%inclusion3 decks25 decks
6%synergy
Fabled Passage
12%inclusion3 decks25 decks
10%synergy
Myriad Landscape
12%inclusion3 decks25 decks
-14%synergy
Mirrex
12%inclusion3 decks25 decks
11%synergy
Malakir Rebirth
12%inclusion3 decks25 decks
-11%synergy
Prismatic Vista
8.0%inclusion2 decks25 decks
6%synergy
The Mycosynth Gardens
8.0%inclusion2 decks25 decks
7%synergy
Talon Gates of Madara
8.0%inclusion2 decks25 decks
6%synergy
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